If you read the F-16 DSI program, it was undertaken with minimal or no changes to the rest of the aircraft. All these changes are centered on the airflow underneath the aircraft, not above it. You will probably get even better lift.
As for the nose, they would have to sort it out with a wind tunnel. My feeling is that this nose is even more streamlined than the previous one, and has none of the boundary layer intake issues as the old one. The flatter nose also contributes to lift which improves the planes lift drag ratio.
This will surely cause need some tweaks on the FCS, and definitely the extension on the rudders and ventral fins are a consequence of this.