Some redlines can be bypassed and talked around, yes, but others ? not so much. You can argue that the west bank is doomed, and I'll probably agree with you, but what can Israel do about Al Aqsa mosque and unrestricted muslim access to it through the heart of their "supposed" capital (this was a condition Saladin agreed to wrt Christians with Richard the lionheart to end the crusades, I don't think Israel will ever agree to this, no modern nation will) ? What can it do to Hamas (the US lost to Taliban, remember that) ? What can it do to Gaza ? The answer is nothing that won't trigger Armageddon.
Also, how will Israel deal with Pakistan, a nation whose population is super fundamentalist (even by Islam's standards!), Syria, Hezbollah and especially Iran? The latter is spending billions of dollar building underground fortresses (actually capable of stopping Bunker Buster bombs of any size. Check the video on the CuriousDroid youtube channel), ballistic missiles, drone carriers, increasingly advanced submarines, etc. You think they don't plan on eventually using them ?
As for the USA remaining a super power with influence in the middle east, people said that about the soviet union too. See how that turned out ? (BTW the US's internal problems now are far more severe than USSR untill it's very last couple of years).