Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

taxiya

Brigadier
Registered Member
When you say 2nd gen, is that tailored against Omicron or Delta?
I would rather think that it is not tailored for any specific variant, but tailored for all (as much as possible) possible offspring. Otherwise there is no difference from current vaccines and should not have used the designation "broad spectrum".
 

AndrewS

Brigadier
Registered Member
I would rather think that it is not tailored for any specific variant, but tailored for all (as much as possible) possible offspring. Otherwise there is no difference from current vaccines and should not have used the designation "broad spectrum".

I see mention of Beta and Delta for the 2nd Gen Sinopharm vaccines

pharmaceutical-technology.com/news/sinopharm-two-drugs-covid/
 

Phead128

Captain
Staff member
Moderator - World Affairs
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So much truth! So based!

Alex Lo is the only reason SCMP has any shred of credibility. Him and the Chief news editor Yoden Lhatoo.

Western criticism of China mainly come from China not contributing their fair share of deaths. Not enough dead Chinese to satisfy these racist imperialist fkers.
 

gelgoog

Brigadier
Registered Member
When you say 2nd gen, is that tailored against Omicron or Delta?

The article says Delta. So much for the talk mRNA leads to faster vaccines. This is a traditional vaccine and it is coming out much faster than the mRNA one.

I think mRNA vaccine is just a gigantic marketing ploy for established pharma players to stamp out any competition with lock in by patents on "novel" vaccine delivery mechanisms. Which haven't been properly tested or guaranteed to be safe in the long run. It is a giant experiment.
 

Bellum_Romanum

Brigadier
Registered Member
So much truth! So based!

Alex Lo is the only reason SCMP has any shred of credibility. Him and the Chief news editor Yoden Lhatoo.

Western criticism of China mainly come from China not contributing their fair share of deaths. Not enough dead Chinese to satisfy these racist imperialist fkers.
Because they really really are so ever desperate to get rid of the See See Pee. Well, too freaking bad, when they can't even bring themselves to respect and properly attribute the name of their supposed strategic opponent that is the CPC then you know why the west can't prevail or expected to win.

The most often quoted word of Sun Tzu: "If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat. If you know neither the enemy nor yourself, you will succumb in every battle." America and her so called allies are falling and failing because they don't seem to want to know or understand their enemies, they presume to know based on their pre-conceived assumptions that are unfortunately based on misguided and arrogant superiority a.k.a. RACISM.

So it doesn't matter how many times these folks read or memorize Sun Tzu's book or any of Chinese strategic classics when their guiding principle is based on a supposition that their way is superior and that China is inferior then all is for naught.
 

taxiya

Brigadier
Registered Member
I see mention of Beta and Delta for the 2nd Gen Sinopharm vaccines

pharmaceutical-technology.com/news/sinopharm-two-drugs-covid/
It is not surprising that Beta and Delta were mentioned because they are the only available variants that any new vaccine can be tested against. It doesn't mean the vaccine is specifically designed against them.

Here is the Chinese source from Sinopharm's head of research institute Li Qiming:
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一代设计抗原蛋白时用的是病毒原型株的部分蛋白,如新冠病毒的S蛋白的关键区域。而二代疫苗研发,在抗原的设计上就不一样。

研发团队主要负责人、国药中生生物技术研究院院长李启明进一步解释,针对变异株流行的新趋势,在第一代疫苗的基础上,利用计算结构疫苗学技术平台,通过分子模拟和计算建模方法,对各种变异突变位点的免疫逃逸能力进行了全面的定量计算评估,研发团队设计开发了第二代重组新冠疫苗。

据了解,二代免疫抗原不局限于此前业内聚焦的新冠病毒S蛋白关键区域。也就是说,一代“照猫画虎”越像越好,而二代建模分析、计算评估,有“揣摩神韵”的意思,因此在激发抗体方面,更具“智能”。


Basically, he says that between 1st gen and 2nd gen:
  1. The design of antigen is different.
  2. The 2nd gen covers all (many more) possible mutation points.
  3. Simply put, 1st gen is like copy/pate trying to emulate the virus specific variant as much as possible. The 2nd gen is to model the essence by removing the superficial, more intelligent.
Another Sinopharm source
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目前,该新冠疫苗在阿联酋已接种近2000名受试者,初步的研究结果显示,该疫苗安全性和耐受性好,可激发人体产生针对原型株和主要变异株高水平的中和抗体,充分体现了重组蛋白疫苗技术路线在疫苗研发中的优势和特点。

Here it says that the 2nd gen vaccine is equally effective in generating antibody against the original and other major variants. This means that they tested on all well known variants and all works the same proving the "broad spectrum"/non variant speciality.

I would make a very rough analog. The 1st gen is like "The animal has black hair, no tail, moving on four legs, it is an ape. But an orangutan is not an ape because the hair is orange." The 2nd gen is like "All animals having no tail and walking on four are apes." I know there are other tailless land animals other than apes, but hope you get the idea.
 

KYli

Brigadier
42% of cases in Tianjin are moderate cases which mean some kind of pneumonia. Therefore, Omicron can't be treated as flu yet.
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今日(1月26日),天津市疾病预防控制中心副主任张颖表示:奥密克戎是否是“大号流感”,还需要继续观察,需要更多证据。但疫情病例临床表现来看,确实它不能被看作是大号流感。


奥密克戎(Omicron)自2021年11月出现以来,已有128个国家和地区报告发现了奥密克戎变异株。世卫组织称,新冠病毒奥密克戎变异毒株在全球总体风险评估为“非常高”,传播速度非常快。虽然已经感染了多个国家成千上万名的民众,但是由于大部分人的临床反应没有德尔塔等毒株强烈,因此有人将其称为“大号流感”。


张颖表示:“在所研究361例阳性感染者里面,有42%是普通型,从临床诊断上来说,普通型无论是轻还是重,是有肺炎的表现。对于疾病来说,如果有肺炎占比能达到42%,就不能等同于大号流感。因为我们都知道流感病毒所造成的疾病是以上呼吸道症状为主,会有慢性基础性疾病的人群,会合并肺炎,细菌性的肺炎或病毒性的肺炎,但比例是远远要少于42%的构成比。就目前天津疫情来说,我个人觉得对它是大号流感持一个观望,还是需要在临床上继续来观察。”


前瞻经济学人APP资讯组
 
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