This seems self-defeating considering what an underperforming market could do to the national psychology of Israel.
There was an account that did mention that hitting the rich areas of Israel to tank their real state value and the portfolios of the people that run the country would do more to force its collapse or at least to get rid of Netanyahu by any means, than trying to wipe out an air base, since they, until now, have been largely isolated from the effects of the wars Netanyahu has caused.
Nothing stops them from updating their policies on when the use of nuclear weapons is permissible, or Trump can just ignore long-standing norms and make a decision on a whim.
Trump is known to be unconventional by the norms of the American presidency. He can be convinced to concur with the employment of nuclear weapons.
The only real question here is what he'll want and get in return should such a scenario materialize.
I'm not sure they'll go as far as deploying a nuke, but who knows. Trump's senility seems to be spiking lately