Chinese researchers revolutionizing 140-year-old traditional industrial processes.
This team's published findings present a groundbreaking new method for direct deamination functionalization using N-nitramines. This method efficiently converts inert aromatic carbon-nitrogen bonds directly into various important chemical bonds (including carbon-halogen, carbon-oxygen, carbon-nitrogen, and carbon-carbon bonds).
This approach requires only common laboratory reagents and can efficiently achieve kilogram-scale synthesis of the target product. It overturns the traditional process used in industry for 140 years , providing a safe and economical new solution for aryl diazo chemistry, which has been widely used but limited by its explosiveness and high risks. This method is expected to find widespread application in several important fields such as pharmaceuticals and materials manufacturing.