News on China's scientific and technological development.

Michaelsinodef

Senior Member
Registered Member
It's Stephen Chen, the same guy who always portrays research papers as something they aren't. Textbook clickbait. Do a search on this forum for his name, you'll get plenty of examples.
Oh I know, that's why I said I'm not leaning towards the theory of it being intentional leaks or signalling.
 

gadgetcool5

Senior Member
Registered Member
Why was this tested only on the F-22 configuration and not the B-21 Raider? Would this apply to the latter's stealth capabilities or no?
 

AndrewS

Brigadier
Registered Member
I don’t quite understand the importance of this but bole machinery has built world largest magnesium thixomolding machine. China is the world’s largest magnesium producer so this isn’t a surprise

it’s not clear to me how many ev models us large magnesium parts
Please, Log in or Register to view URLs content!

There's a video below which investigates magnesium versus aluminium castings.

youtube.com/watch?v=wbXGplRrCqY

"In this video I'll walk you through why Thixomolded Magnesium is better than Gigacast Aluminum. In short, it's lighter, creates fewer restrictions on casting designs, and it should become increasingly low cost as the decade progress. To round out the video, I'll also walk you though two use cases, underbody castings and wheels, and how much magnesium we can expect to be used in vehicles and when."
 

sunnymaxi

Captain
Registered Member
WHAT ..

Nanjing University scholars have discovered that a type of vesicle in young blood has the ability to extend lifespan, reverse age-related degeneration, and restore overall physiological function, with effects that exceed those of calorie-restricted diets, niacinamide, etc..

Abstract​

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific rejuvenating mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from the plasma of young mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection of young sEVs into aged mice extends their lifespan, mitigates senescent phenotypes and ameliorates age-associated functional declines in multiple tissues. Quantitative proteomic analyses identified substantial alterations in the proteomes of aged tissues after young sEV treatment, and these changes are closely associated with metabolic processes. Mechanistic investigations reveal that young sEVs stimulate PGC-1α expression in vitro and in vivo through their miRNA cargoes, thereby improving mitochondrial functions and mitigating mitochondrial deficits in aged tissues. Overall, this study demonstrates that young sEVs reverse degenerative changes and age-related dysfunction, at least in part, by stimulating PGC-1α expression and enhancing mitochondrial energy metabolism.

Please, Log in or Register to view URLs content!
 

vincent

Grumpy Old Man
Staff member
Moderator - World Affairs
WHAT ..

Nanjing University scholars have discovered that a type of vesicle in young blood has the ability to extend lifespan, reverse age-related degeneration, and restore overall physiological function, with effects that exceed those of calorie-restricted diets, niacinamide, etc..

Abstract​

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific rejuvenating mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from the plasma of young mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection of young sEVs into aged mice extends their lifespan, mitigates senescent phenotypes and ameliorates age-associated functional declines in multiple tissues. Quantitative proteomic analyses identified substantial alterations in the proteomes of aged tissues after young sEV treatment, and these changes are closely associated with metabolic processes. Mechanistic investigations reveal that young sEVs stimulate PGC-1α expression in vitro and in vivo through their miRNA cargoes, thereby improving mitochondrial functions and mitigating mitochondrial deficits in aged tissues. Overall, this study demonstrates that young sEVs reverse degenerative changes and age-related dysfunction, at least in part, by stimulating PGC-1α expression and enhancing mitochondrial energy metabolism.

Please, Log in or Register to view URLs content!

Peter Thiel is a visionary
Please, Log in or Register to view URLs content!
 

measuredingabens

Junior Member
Registered Member
WHAT ..

Nanjing University scholars have discovered that a type of vesicle in young blood has the ability to extend lifespan, reverse age-related degeneration, and restore overall physiological function, with effects that exceed those of calorie-restricted diets, niacinamide, etc..

Abstract​

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific rejuvenating mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from the plasma of young mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection of young sEVs into aged mice extends their lifespan, mitigates senescent phenotypes and ameliorates age-associated functional declines in multiple tissues. Quantitative proteomic analyses identified substantial alterations in the proteomes of aged tissues after young sEV treatment, and these changes are closely associated with metabolic processes. Mechanistic investigations reveal that young sEVs stimulate PGC-1α expression in vitro and in vivo through their miRNA cargoes, thereby improving mitochondrial functions and mitigating mitochondrial deficits in aged tissues. Overall, this study demonstrates that young sEVs reverse degenerative changes and age-related dysfunction, at least in part, by stimulating PGC-1α expression and enhancing mitochondrial energy metabolism.

Please, Log in or Register to view URLs content!
Mitochondrial dysfunction is one of the hallmarks of aging. Solving this issue is another step towards true rejuvenation therapies.

On the topic of blood, however, there's a whole slew of things happening to the blood during aging. One of these things is a massive loss in the diversity of red blood cell lines in the human body after ~70 years of age due to the build up of mutations. The lines of cells that do their job properly either become hampered due to said mutations and/or are outcompeted by cells with mutations that favour proliferation over function.
Please, Log in or Register to view URLs content!
Please, Log in or Register to view URLs content!
 

dingyibvs

Junior Member
There's a video below which investigates magnesium versus aluminium castings.

youtube.com/watch?v=wbXGplRrCqY

"In this video I'll walk you through why Thixomolded Magnesium is better than Gigacast Aluminum. In short, it's lighter, creates fewer restrictions on casting designs, and it should become increasingly low cost as the decade progress. To round out the video, I'll also walk you though two use cases, underbody castings and wheels, and how much magnesium we can expect to be used in vehicles and when."
Aren't magnesium shavings quite flammable? Might that be an issue for some use cases?
 
Top