Coronavirus 2019-2020 thread (no unsubstantiated rumours!)

vincent

Grumpy Old Man
Staff member
Moderator - World Affairs
Majority of the time spent on vaccine development is testing. The quickest vaccine development in history before COVID is the MMR vaccine (inactivated) and it took four years. Creating vaccines don’t take long, but proving them have no negative health effects, both short-term and long-term, plus the efficacy takes most of the development time.
Using myself as example, I took the first shot of Novavax vaccine awhile ago. 6 days after the shot, I had tightness in my chest for two days. It was unlikely to be heart burn since I rarely rarely get it and never last for days. Now the FDA noted the Novavax can cause myocarditis. I haven’t heard much negative about Chinese inactivated vaccines.
 

Coalescence

Senior Member
Registered Member
Using myself as example, I took the first shot of Novavax vaccine awhile ago. 6 days after the shot, I had tightness in my chest for two days. It was unlikely to be heart burn since I rarely rarely get it. Now the FDA noted the Novavax can cause myocarditis. I haven’t heard much negative about Chinese inactivated vaccines.
About Novavax, I've been seeing a lot of cheerleading in twitter by some users claiming its a sterilizing vaccine and that it is the key to stopping the pandemic. Is it true or are they just paid shills?
 

vincent

Grumpy Old Man
Staff member
Moderator - World Affairs
About Novavax, I've been seeing a lot of cheerleading in twitter by some users claiming its a sterilizing vaccine and that it is the key to stopping the pandemic. Is it true or are they just paid shills?
The working principle of Novavax is the same as Biontech and Moderna’s, the COVID virus’ spike proteins (manufactured in Novavax factories instead of using people’s cells like in mRNA vaccines) will trigger immune response from the body. I’m just an engineer, but my suspicion is the spike proteins trigger the immune response by sticking to cells which the immune system recognizes as a viral infection and starts to destroying the cells with spike proteins on them. That’s why all of them cause myocarditis because the spike protein will poke any cells they encountered which include heart tissues.
 

Phead128

Captain
Staff member
Moderator - World Affairs
The Chinese government and commercial companies invested in mRMA primarily for the technology and potential applications in other diseases, like certain form of cancer and heart disease for example,
Primarily cancer? Not really....

CanSino, SinoPharm, Abogen/Walvax, AIM vaccine, Stemirna Therapeutics, Everest, CSPC pharma, that is 7 clinical trials for COVID mRNA vaccines.

Now...Name one clinical trial by Chinese companies for cancer? It's clearly primarily COVID given the number of clinical trials.
AThere are many alternate technology for Covid-19 vaccines available that are just as effective,
There are other advantages such as fast, scalable and uniform production. Even state-owned Giants like SinoPharm seeking to develop its own mRNA vaccine under CCP guidance and funding.

Zhu Jingjin, the Chinese Communist party secretary of China National Biotec Group, a unit of Sinopharm, said it was developing an mRNA vaccine as well as a broad-spectrum recombinant protein vaccine that was in clinical trials.
Paywall bypass:
Please, Log in or Register to view URLs content!

CanSino, the makers of traditional vector COVID vaccine, has gained Chinese approval for clinical trials for mRNA vaccine.

So if Chinese traditional inactivated vaccine makers like SinoPharm and CanSino are seeking their own mRNA vaccines, can you really say it's not required based on efficacy alone?

Has the Chinese government allow any of them in the domestic market?
Not yet but CanSino, SinoPharm, Abogen/Walvax, AIM vaccine, Stemirna Therapeutics, Everest, CSPC pharma,have at least is 7 clinical trials at various stages for COVID mRNA vaccines.

The Abogen/Walvax one is backed by PLA military is the most promising one given it's at phase 3 trial.
 
Last edited:

Phead128

Captain
Staff member
Moderator - World Affairs
Using myself as example, I took the first shot of Novavax vaccine awhile ago. 6 days after the shot, I had tightness in my chest for two days. It was unlikely to be heart burn since I rarely rarely get it and never last for days. Now the FDA noted the Novavax can cause myocarditis. I haven’t heard much negative about Chinese inactivated vaccines.
I had the same exact experience with Pfizer. 7 days after my 2nd shot of Pfizer mRNA, I had tightness in my chest, fatigue, and dizziness for few days, I've never experienced that before... Few weeks later, I read an article from FDA saying there is a chance mRNA can cause myocarditis/pericarditis, so I immediately went to emergency room to get tested, but the D-dimer and troponin levels indicated no myocarditis/pericarditis. Instead, these doctors say it: 1) esophageal spasm, 2) acid reflux, 3) heartburn, which is bullshit. I am 100% sure it was vaccine-related, so I reported my symptoms to CDC's VAERS, and I spoke with a gastroenterologist, who said it's highly unlikely to be acid reflux or esophageal spasm. So it is 100% vaccine-related.

Just yesterday, a claims-analysis published in the Lancet reported the risk was highest among young men 18-25 with 1.7 per 100,000 person-years of myocarditis/pericarditis with Pfizer mRNA after their 2nd dose. (Source:
Please, Log in or Register to view URLs content!
) I'm basically in early 30's so somewhat in that cohort, but the older you are, the less likely of developing myocarditis post-mRNA vaccine.

BUT... with that said, I still got my 3rd booster shot (no side-effects), because I know the risk of myocarditis/pericarditis is even higher from COVID infection than from mRNA vaccines itself. According to
Please, Log in or Register to view URLs content!
, the excess risk of myocarditis with mRNA is 1-6 extra cases per 1 million, compared to 40 extra cases per 1 million after COVID infection. In other words, if I got COVID, the risk of myocarditis is higher than from vaccination itself. So I'd rather take my chances with the vaccine than with COVID itself.
 

tokenanalyst

Brigadier
Registered Member
Very concerning numbers, hope they can get it down quickly. from this source, 52 symptomatic cases were converted from asymptomatic cases.
Please, Log in or Register to view URLs content!
Is concerning but the ratio is of symptomatic vs asymptomatics is still low which could mean the outbreak is still "visible" therefore containable without a mayor lockdown, concerning would be if the ratio between symptomatic vs asymptomatics is high because that mean that the outbreak is not containable and a mayor lockdown is required.​
 
Top