I doubt US is really concerned about MQ-9 Reaper losses. According to the 2025 Air Force Almanac, there are 230 MQ-9 Reapers in service with an average airframe age of ~7.2 years. Given that losses of MQ-9's don't cost human lives, and when combined with the relatively large inventory (along with low age of airframe), I think these platforms might be viewed as expendable (to an extent).
Also, I think we need to stop talking about US losses in dollar terms. For a country like the US, a couple hundred million in drone losses is not of material concern. They are talking about a $50 billion supplementary package to fund munition replenishment for the War in Iran, on top of a ~$450 billion reconciliation bill (or just raising Defense spending by ~50%) to bring defense spending to $1.5 trillion.
If you want to talk about US losses, look the difficulty in replacing AN/TPY-2 radars due China's stranglehold on GaN (and other rare earth mineral) production.
Wouldn't basing be more of a concern than attrition for MQ-9 drones? If US loses basing access in Arab countries, do these drones even have enough range to do a round trip while launching from Israel? I guess they can still be launched from aircraft carriers in the Indian Ocean